To evaluate anti-convulsant activity of different extracts of Jasminum sambac, Chamomilla capitula, Lilium candidum and Sorghum halpense in rats. The effects of single administration of different preparations of Jasminum sambac, Chamomilla capitula, Lilium candidum, Sorghum halpense were evaluated for their anticonvulsant profile in the Maximal Electroshock Seizure (MES) and Pentylene tetrazole (PTZ) test in rats. The standard drug diazepam (10 mg/kg) was used for comparison. The crude drug of Jasminum sambac, Chamomilla capitula, Lilium candidum, Sorghum halpense (200 and 400 mg/kg) showed mild to moderate anticonvulsant activity. The antiepileptic drugs such as diazepam restored the monoamine levels on brain. Similarly EEJs, EELc, EESh, EECc, EEJSLC significantly increased monoamines levels in forebrain of rats. The anticonvulsant activity against seizures induced by MES and PTZ was performed. MES is probably the best validated method for assessment of anti- epileptic drugs in generalized tonic-clonic seizures. EEJSLC extract showed significant increased GABA content in brain dose dependently. This suggests that the anticonvulsant activity of EEJSLC extract is probably through elevation of brain GABA content.
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